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Informaciones
Psiquiátricas
2019 - n.º
236
De un amplio conjunto de medidas clínicas,
cognitivas, analíticas, funcionales, factores
de riesgo cardiovasculares y farmacológicos,
únicamente observamos que las personas
con lesiones de sustancia blanca presenta-
ban diferencias significas significativas so-
bre las que no presentaban estas lesiones:
un cociente intelectual verbal medio infe-
rior, resultados medios en el Mini-Examen
Cognoscitivo inferiores y niveles medios de
homocisteína superiores.
Conclusiones:
En el grupo estudiado de pacientes con es-
quizofrenia existe una elevada prevalencia
de lesiones en la sustancia blanca. Las pa-
cientes que tienen esta patología tienen un
mayor deterioro cognitivo y un nivel de ho-
mocisteína más elevado.
Palabras clave:
Esquizofrenia, deterioro cog-
nitivo, envejecimiento, enfermedad cerebro-
vascular, homocisteína.
Abstract
ELDERLY PATIENTS WITH SCHIZOPHRENIA.
COGNITIVE IMPAIRMENT AND RELATED
FACTORS
Introduction:
Today, cognitive dysfunction is accepted as
a further feature of schizophrenia. As the
patients age, this dysfunction is higher and
harder to evaluate due to the interaction of
cognitive impairment associated with age,
other somatic diseases as neurological and
cardiovascular disorder, psychoactive drug
interactions, etc.
Aim of the study:
In a group of patients with severe schizo-
phrenia, drug resistant, interned for years,
who have been explored for more than 31
years by us, we study his cognitive dys-
function as well as other biological, clinical,
analytical or pharmacological variables and
his relationship with cerebrovascular disease.
Method:
The 16 surviving patients from the initial
sample are given a computerized axial to-
mography, analytics, clinical and neurop-
sychological explorations and present disea-
ses, drug treatments, etc, are collected.
Results:
We found extensive and confluent white
matter lesions in 43, 8% of the cases.
From a wide ensamble array of clinical, cog-
nitive, analytical and functional measures,
cardiovascular and pharmacological risk fac-
tors, we only found that people with white
matter lesions presented significantly lower
verbal intellectual ratios than those who did
not, lower results at the Mini Cognitive Exa-
mination and higher average levels of homo-
cysteine.
Conclusions:
There is a high prevalence of white matter
lesions in the group of patients with schizo-
phrenia. Patients who have this pathology,
also have higher cognitive dysfunction and
increased homocysteine levels.
Key Words:
Schizophrenia, cognitive dys-
function, aging, cerebrovascular disease,
homocysteine.
Emilio González-Pablos / Rosa Sanguino-Andrés / José A López-Villalobos / Federico Iglesias-Santa Polonia /
Guillermo Hoyos-Villagrá / Clara González-Sanguino / Carlos Martín-Lorenzo