24 Informaciones Psiquiátricas 2025 - nº 259 tipsicóticos, especialmente los de segunda generación, pueden contribuir a la pérdida ósea debido a efectos secundarios como aumento de peso y desequilibrios hormonales. La discusión resalta que la relación entre ambas condiciones es compleja y multifactorial, involucrando factores de estilo de vida, efectos de los medicamentos y condiciones biológicas. Se sugiere un manejo integral que incluya seguimiento regular, promoción de un estilo de vida saludable y tratamientos adecuados. Se recomienda realizar densitometrías óseas para detectar la osteoporosis de manera temprana y guiar intervenciones, así como fomentar una dieta rica en calcio y vitamina D y la práctica de actividad física regular. Palabras clave: Esquizofrenia, Osteoporosis, Densidad Mineral ósea, factores de riesgo, antipsicóticos. Abstract The article addresses the relationship between schizophrenia, which affects approximately 1% of the global population, and osteoporosis, a disease that decreases bone density and quality, increasing the risk of fractures. People with schizophrenia often lead a sedentary lifestyle and have unhealthy habits, which increases their risk of developing osteoporosis. We present a clinical case of a 60-year-old woman diagnosed with schizophrenia, treated with antipsychotics and, occasionally, corticosteroids, osteoporosis and bone fractures secondary to falls, with compromised quality of life. A review of the scientific literature was conducted to examine this association, analysing common risk factors and the impact of pharmacological treatments. The results indicate that the prevalence of decreased bone mineral density in patients with schizophrenia is significantly higher than in the general population, reaching up to 65.3% in hospitalized patients. Antipsychotics, especially secondgeneration ones, may contribute to bone loss due to side effects such as weight gain and hormonal imbalances. The discussion highlights that the relationship between both conditions is complex and multifactorial, involving lifestyle factors, medication effects, and biological conditions. An integrated management approach is suggested, including regular follow-up, promotion of a healthy lifestyle, and appropriate treatments. It is recommended to perform bone density tests to detect osteoporosis early and guide interventions, as well as to encourage a diet rich in calcium and vitamin D and regular physical activity. Keywords: Schizophrenia, Osteoporosis, Bone Mineral Density, Risk Factors, Antipsychotic. María Socorro Soriano García / Sandra Duque Tarrés
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